Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) use your own platelets and growth factors to support repair and collagen. Longevity differs because each concentrate releases those signals on a different timeline. PRP delivers growth factors fast. PRF uses a fibrin matrix to slow and extend release. This core biology explains why maintenance schedules vary.
PRF vs PRP: why duration differs
PRP contains platelets suspended in plasma. After injection, growth factors surge early and then decline. PRF includes a fibrin scaffold that traps platelets and white blood cells and acts like a time-release system. Studies show PRF provides steadier, longer growth-factor output over several days, while PRP peaks earlier.
This difference shapes real-world timelines. Areas that benefit from a quick boost may suit PRP. Delicate zones and texture work often benefit from PRF’s gradual signaling.
How long do results last by area?
Under-eyes and facial rejuvenation
Goal: brighten hollows, smooth fine lines, and enhance skin quality. Expect change to build over weeks as collagen forms. Many patients complete a short series, then top up as needed. Because PRF releases signals more slowly, practices often space PRF maintenance a bit farther than PRP. Individual plans vary by skin condition, dose, and technique.
Hair restoration
Goal: reduce shedding and improve density. The American Academy of Dermatology outlines a common medical schedule: monthly sessions for three months, then maintenance every three to six months. Providers adjust based on shedding patterns and adjuncts.
Texture and scar remodeling
For acne scars and overall texture, PRF’s longer release can support remodeling windows that extend beyond the injection day. Some protocols combine PRF with microneedling or energy devices for compounded effect.
Choosing PRF vs PRP for your treatment area
Choosing the right concentrate starts with the healing process you need. PRP platelet rich plasma delivers high concentrations of platelets and growth factors quickly, which suits treated areas that need a faster boost. PRF platelet rich fibrin forms a fibrin mesh that holds platelets, white blood cells, and cytokines, so concentrations of growth factors release slowly and evenly.
This pattern benefits delicate zones such as the eye area and any treatment area where gradual collagen building enhancing skin texture matters. Your skin condition, medical history, and aesthetic goals guide the plan. In some cases, PRF offers longer spacing between sessions; in others, PRP pairs well with energy devices or dermal fillers to keep results steady.
We individualize the treatment option by dose, depth, and interval for each patient and site. To map the best schedule and maintenance calendar for you, schedule a consultation with our clinicians to review goals, photos, and response.
Typical maintenance schedules (illustrative)
Your injector will tailor these to your goals and treated areas.
- Under-eyes / face (PRF): 2–4 sessions, 4–6 weeks apart; maintenance guided by response and photos. Evidence supports PRF’s slower, sustained release between visits.
- Under-eyes / face (PRP): often 3 monthly sessions; maintenance as needed.
- Hair (PRP): monthly x3, then every 3–6 months during year one; intervals may widen if density stabilizes.
Longevity by Area: What to Expect
During PRF or PRP care, blood is drawn and spun to concentrate platelets and growth factors. These signals support blood vessels, reduce inflammation, and begin boosting collagen in treated areas. For the delicate eye area and fine lines and wrinkles, plans differ. PRF under eyes—how long does it last? Results vary depending on dose, skin type, and the concentration of growth factors; many patients see steady skin improvements with PRF facial rejuvenation longevity.
PRP under eyes results duration can be shorter because release is faster, while PRP skin treatment longevity in larger zones may need more frequent visits and recovery time. For thinning hair, PRF hair restoration—how long does it last—also depends on schedule. Overall PRF vs PRP longevity and the PRF vs PRP maintenance schedule reflect your skin condition and aesthetic goals. We review blood samples, technique, and mesenchymal stem cells to choose the right treatment option. Schedule consultation.
What actually drives longevity?
- Biology of the concentrate: PRP = early peak; PRF = steady multi-day release. Area and skin thickness: the eye area changes slowly and needs series-based planning.
- Concentration and method: spin speed and leukocyte content affect concentrations of growth factors and outcomes.
- Adjuncts: skincare, sun protection, and hair medications can support results when appropriate.
Safety and regulation, in brief
These are autologous treatments. Outcomes vary by indication and protocol. Dermatology guidance notes that patients usually need repeat sessions and a maintenance plan. Choose a trained medical team that follows sterile technique and device best practices.
Quick FAQ
How long do PRF injections last?
Many patients maintain improvement for months after a short series, with maintenance set by response and goals. PRF’s sustained release supports longer spacing in some plans.
PRP injections—how long do they last?
Most hair protocols use monthly sessions for three months, then every 3–6 months. Facial schedules are individualized.
PRF vs PRP under the eyes—what is the difference in duration?
Both aim to stimulate collagen. PRF releases growth factors more slowly, which can support steadier remodeling between visits. Exact duration varies by anatomy and dose.
Can PRP and PRF be combined?
Yes. Some plans use PRP for quick onset and PRF for a longer tail. Your injector will time sessions to avoid overlap and to protect healing.
Planning your course at PURE (Chicago)
At PURE Medical Spa (River North on N. Dearborn, Old Orchard/Skokie, Oakbrook, Roscoe Village), we map the treatment area, goals, and medical history to a simple calendar. For hair, we follow the AAD-supported cadence first, then extend intervals as results stabilize. For the eye area, we set conservative doses and document changes with standardized photos. We adjust concentrations and spacing to meet your aesthetic goals without over-treating.
Next steps:
- Learn more: Does PRF Under the Eyes Actually Work?
- See timing: How Long Does It Take to See Results from PRF?
- Ready for a plan built around you? Schedule a consultation
References
- Growth-factor kinetics: PRF provides slower, sustained release vs PRP; comparative and kinetic data. PMC+2PMC+2
- Hair schedule guidance: American Academy of Dermatology patient guidance on PRP frequency. American Academy of Dermatology+1
- Method factors: preparation variables influence growth-factor output. PMC
