PRP vs PRF: Which Natural Rejuvenation Treatment Fits You?

-Introduction: Natural Regeneration Is the Future of Aesthetics

In today’s world of aesthetic medicine, clients are increasingly drawn to treatments that work with the body rather than against it. Instead of simply masking concerns, the focus is shifting toward natural anti-aging solutions that stimulate long-term repair and regeneration. This is where PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin) come in. Both treatments use your body’s own platelets to stimulate collagen, restore volume, and improve skin tone. But while the names sound similar, the science and results are not identical.

If you’re considering regenerative therapies, understanding PRP vs PRF is key to making an informed decision. Let’s explore how they work, their benefits, and how to decide which treatment is right for you.

What Is PRP?

Platelet-Rich Plasma (PRP) has been used in medical settings for decades, from orthopaedic healing to wound repair. In aesthetics, PRP is prepared by drawing a small amount of blood, spinning it in a centrifuge, and separating out the plasma that’s rich in platelets and growth factors.

When injected into the skin or combined with treatments like micro needling, PRP delivers a boost of collagen stimulation and cellular repair most commonly used for:

• Skin rejuvenation (improving texture and tone)
• Under-eye treatment for dark circles and hollowness
• Hair restoration for thinning hair in both men and women

PRP works by targeting the areas where regeneration is most needed, encouraging new tissue growth and natural healing.

What Is PRF?

Platelet-Rich Fibrin (PRF) is the next generation of platelet therapy. Like PRP, it’s derived from your blood, but the preparation method is different. With PRF, blood is spun at a slower speed, which preserves more white blood cells and a fibrin matrix. This results in a concentrate that releases growth factors more slowly and naturally over time.

PRF also contains stem cells, making it a more powerful option for natural anti-aging and volume restoration. Unlike PRP, which delivers a quick burst of growth factors, PRF continues to release healing elements for several days after treatment. This creates a longer-lasting effect and often requires fewer sessions overall.

PRF is most commonly chosen for:

• Under-eye rejuvenation (a safer, natural filler alternative)
• Skin texture and acne scars
• Subtle volume replacement in delicate areas

PRP vs PRF: The Key Differences

Both PRP and PRF work by using your body’s healing properties, but there are important distinctions:

In short, PRP is effective for stimulating general healing and hair growth, while PRF provides a more natural filler-like effect for delicate areas.

Who Is a Good Candidate for PRP vs PRF?

Both treatments are safe and effective because they use your own blood eliminating the risk of allergic reactions. However, the right option depends on your specific goals:

• Choose PRP if:
• You’re focused on hair restoration or scalp treatments.
• You want to improve skin tone and texture with microneedling.
• You prefer a proven treatment that has been used widely for years.
• Choose PRF if:
• You want a natural alternative to fillers under the eyes.
• You’re concerned about subtle volume loss or skin laxity.
• You’re looking for longer-lasting regenerative effects.

At Pure Medical Spa in Chicago, your provider will review your concerns and create a customized plan that may even combine both therapies for maximum results.

What to Expect During Treatment

Both PRP and PRF treatments are relatively quick and minimally invasive. Here’s what most patients experience:

1. Blood Draw: A small sample of your blood is collected.
2. Centrifuge Processing: The blood is spun at different speeds, depending on PRP or PRF.
3. Injection/Topical Application: The concentrate is applied to the skin or scalp, or injected into areas like the under eyes.
4. Recovery: Mild redness, swelling, or bruising may occur, but downtime is minimal.

Most patients notice improvements in texture and glow within weeks, with continued improvements over several months as collagen stimulation takes place.

Cost of PRP vs PRF in Chicago

Pricing varies depending on the treatment area and number of sessions. On average in Chicago:

• PRP sessions range from $500–$900 per treatment (packages are common for hair restoration).
• PRF sessions range from $600–$1,200 per treatment, often recommended for under-eye or facial rejuvenation.

At Pure Medical Spa, consultation is the first step to determine the right plan and provide a clear treatment roadmap with transparent pricing.

PRP and PRF at Pure Medical Spa

As Chicago’s trusted med spa, Pure specializes in advanced regenerative treatments like PRP and PRF. Our expert injectors tailor each session to your aesthetic goals whether you’re seeking a refreshed under-eye area, smoother skin, or a natural boost in hair growth. With state-of-the-art technology and a focus on safety, Pure ensures every client receives the highest standard of care.

FAQs: PRP vs PRF

1. Is PRF better than PRP for under eyes?

Yes. PRF is considered safer and more effective than PRP under the eyes because of its slow release of growth factors and natural filler-like effect.

2. How long do PRP and PRF results last?

PRP typically lasts 6–12 months, while PRF results can extend beyond a year, depending on the individual.

3. What is the cost of PRP vs PRF in Chicago?

PRP costs around $500–$900 per session, while PRF ranges from $600–$1,200 per session. Packages are available for multiple treatments.

4. Can PRP and PRF be combined with microneedling?

Absolutely. Combining microneedling with PRP or PRF enhances penetration and results in more dramatic skin rejuvenation.

5. Which is safer PRP or PRF for skin?

Both are safe since they come from your own blood, but PRF is often preferred for sensitive areas causue its gentler, sustained effect.

Call to Action

Ready to explore the benefits of PRP vs PRF for yourself? Book your consultation at Pure Medical Spa in Chicago today and discover which natural regenerative treatment is right for your skin or hair goals.

Full References:

1. Bansal, S., Garg, A., Khurana, R., & Chhabra, P. (2017). Platelet-rich fibrin or platelet-rich plasma – which one is better? An opinion. Indian Journal of Dental Sciences, 9(S1), S49-S52. https://doi.org/10.4103/IJDS.IJDS_55_17
2. El‐said, A. S., Zaky, S., El‐Saygh, A. E. S., Eissa, A. Y., El‐Barkooky, H., & Al‐Sanabani, F. (2022). Fluid platelet-rich fibrin (PRF) versus platelet-rich plasma (PRP) in the treatment of atrophic acne scars: A comparative study. Journal of Cosmetic Dermatology. PMC Article No. PMC10205840.