If you want smoother, brighter skin with little downtime, you’ll see two options everywhere: PRP and PRF. Both come from your own blood. Both aim to trigger repair and collagen. But they are not the same. This guide explains the difference, shows what the research says, and helps you choose what fits your goals.
PRF vs PRP—what’s the difference?
PRP (platelet-rich plasma) is spun at higher speeds and mixed with an anticoagulant to keep it liquid.
PRF (platelet-rich fibrin) is spun at lower speeds without anticoagulants. It forms a soft fibrin network (a gel) that can hold platelets and white blood cells. This fibrin acts like a slow-release “sponge,” which may extend how long growth factors stay active in the skin.
You’ll also see PRFM (platelet-rich fibrin matrix) and “PRF gel” used under eyes or as a natural volumizer. These are thicker, gel-like forms created from PRF.
Platelet rich fibrin (PRF) and platelet rich plasma (PRP) both harness platelets and growth factors to drive the body’s natural healing, yet they act differently. PRF forms a fibrin mesh that allows sustained release of growth signals, helping collagen and elastin rebuild in targeted areas such as acne scars and fine lines and wrinkles.
PRP remains liquid after separating the platelets, making it versatile for microneedling or scalp therapy. How does PRF work in real plans? We pair it with gentle devices, map treatment plans by skin thickness, and layer or alternate with dermal fillers to optimize results safely, overall.
Where does each shine?
Texture, fine lines, acne scars
A 2022 study comparing fluid PRF with and without microneedling versus PRP for atrophic acne scars found PRF-based approaches performed as well or better, with good safety. This supports PRF’s role in skin remodeling when texture is the main concern.
Under-eyes (dark circles, crepe skin)
A 2023 prospective study using PRF matrices around the eyes reported significant gains in periorbital skin rejuvenation and patient satisfaction. This aligns with how PRF’s gel holds growth factors in delicate tissue.
Hair thinning
PRP has more high-quality data for androgenetic alopecia. A 2024 meta-analysis in women showed PRP improved hair density and thickness with a favorable safety profile. PRF for hair is promising, but evidence is earlier.
Bottom line: For texture and delicate areas (like tear troughs), PRF often gets the nod. For hair, PRP currently has stronger evidence. For general glow and fine lines, both help; your plan can combine them.
Safety, downtime, and expectations
Both PRP and PRF use your own blood, so allergy risk is low. Expect brief redness, swelling, or bruise. PRF may feel puffy where the gel sits, especially under eyes, for a few days. Results build gradually over weeks as collagen forms.
If you care about “before and after” results (for example, prf under eyes before and after, prf microneedling before and after, prf face before and after), real outcomes depend on your baseline, number of sessions, and skin care between visits. Your provider should set a clear photo schedule and plan.
What the regulators say (Chicago / Illinois update)
Illinois regulators continue to spotlight medical spa services. In 2025, the Illinois Department of Financial and Professional Regulation (IDFPR) issued notices covering med-spa procedures—explicitly naming platelet-rich plasma among services under medical oversight. This reinforces the need to see licensed, trained injectors in regulated settings.
Also remember: in the U.S., PRP/PRF preparation devices typically carry FDA clearance for specific uses (for example, mixing PRP with bone graft), not for cosmetic claims. Aesthetic use is often off-label, which is common in medicine but calls for informed consent and expert technique.
PRF vs PRP: quick selector
- Crepey under-eyes, fine lines in thin skin: start with PRF/PRFM.
- Acne scars and texture: PRF + microneedling or PRP + microneedling; your provider will pick based on skin and downtime.
- Diffuse dullness or early lines: either PRP or PRF can help; plan a series.
- Hair loss: PRP has stronger evidence today; PRF is emerging.
“Best-in-Class” checklist
- Board-certified or appropriately licensed clinician performs or directly supervises care.
- Device and protocol documented (spin speed, time, tube type; PRP vs PRF clearly labeled).
- Sterile technique and photo-backed treatment plan.
- Clear session map (typically 3–4 visits for skin; quarterly maintenance).
- Informed consent covers off-label status and realistic timelines.
How we build a plan at PURE
- Assess: goals, skin thickness, vessels, and pigment risk.
- Choose: PRF for thin, crepe zones; PRP or PRF for texture; PRP for hair.
- Stack smart: combine with gentle microneedling or energy-based care when appropriate.
- Protect: SPF, barrier repair, and pigment control between visits.
- Track: standardized lighting for honest prf treatment before and after photos.
Want a complementary treatment on glow days? See our HydraFacial MD + Dermaplaning page for pairing ideas. [/hydrafacial-md-dermaplaning-the-gold-standard-skin-glow/]
Explore our PRP and PRF options and book a consultation: PRF & PRP treatments in Chicago [/]
FAQs
What’s the difference between PRP and PRF?
PRP is a liquid plasma rich in platelets, prepared with an anticoagulant. PRF is a fibrin gel without anticoagulant that may release growth factors over a longer window.
Is it normal to combine PRP and PRF (“if prp and prf normal”)?
Yes. Some plans use PRF under the eyes and PRP across the rest of the face or scalp. Your provider will tailor the mix to goals and downtime.
Do I need PRF “gel” or PRFM under the eyes?
PRF gels can add gentle support and deliver factors in thin tissue. They are not dermal fillers and won’t replace high-volume fillers in deeper hollows. A consult can decide if PRFM, standard PRF, or a staged plan fits best.
How many sessions will I need?
Most people plan 3–4 sessions a month apart, then maintenance 2–3 times a year. Hair protocols vary.
Key research:
- Comparative study on PRF vs PRP for acne scars. PMC
- Prospective study on PRF around the eyes and periorbital rejuvenation. PMC
- Meta-analysis showing PRP efficacy in female hair loss. PMC
- PRF in dermatology overview of mechanisms and uses. PMC
- Regulatory context for Illinois med spas; and FDA device indication example. IDFPRS. Food and Drug Administration
