Platelet-based treatments use a patient’s own blood to support repair and renewal. Many people know platelet-rich plasma (PRP). Platelet-rich fibrin (PRF) is the newer option. Both deliver platelets and growth factors to a targeted area. Both sit within regenerative medicine. The key question is simple: Is PRF better than PRP? The best answer is: PRF can perform better for certain goals and zones, while PRP remains an effective, proven tool. Your plan should match your skin concern, downtime, and budget.
PRP vs PRF: what actually differs
- Preparation: PRP uses an anticoagulant and faster spin. This yields concentrated platelets suspended in plasma. PRF uses no anticoagulant and a slower spin, creating a soft fibrin matrix that traps platelets and some white blood cells.
- Release profile: PRP delivers a quick burst of platelets and growth factors. PRF’s fibrin scaffold supports a sustained release of growth factors over days. Laboratory studies show longer growth-factor availability from PRF matrices.
Why that matters: A rapid pulse (PRP) can suit larger surfaces or when you combine sessions with devices. A slower release (PRF) can suit delicate zones like the under-eyes—where steady signaling may support smoother texture with less swelling.
What the evidence says (in brief)
- Skin quality and scars: In an atrophic acne-scar trial, fluid PRF (alone or with needling) improved scars and texture and compared favorably with PRP, with good safety.
- Sustained biology: Independent lab data confirm PRF matrices keep releasing VEGF, PDGF, and TGF-β beyond the first day, supporting continued tissue signaling.
- Aesthetic medicine overview: A 2024 peer-review consolidates clinical uses of autologous platelet concentrates in aesthetics and supports combining PRP/PRF with microneedling, lasers, or RF to optimize outcomes.
Bottom line: Evidence for PRP is broader (e.g., hair loss). PRF data are newer but promising, especially where a slow release and gentle volumizing gel help. Your provider may even combine PRP and PRF in the same plan to leverage both profiles.
Evidence Snapshot
Recent clinical trials and randomized control trials continue to clarify how platelet concentrates work in skin and soft tissues. A study showed that platelet derived growth factors, vascular endothelial growth factors, and transforming growth factors signal the extracellular matrix, blood vessels, and mesenchymal stem cells to repair micro-injury. Because PRF carries more native blood components from a simple blood test and forms a fibrin scaffold, it can sustain these signals beyond the short term. This controlled release may improve clinical outcomes for a wide range of concerns while it reduces the risk of irritation.
In orthopedics and physical therapy, similar biology supports soft tissue recovery; in aesthetics, the same pathways help align treatment plans with specific aesthetic goals. Bone marrow and the immune system also respond to these cues, priming defense and remodeling. To review method details and endpoints, find articles that report standardized protocols, blinded scoring, and safety data.
Choosing between PRP and PRF by goal
- Under-eyes and fine lines (thin skin tones and textures): PRF often suits this targeted area thanks to its fibrin gel and gradual factor release of growth factors.
- Overall glow or device-assists (microneedling, fractional lasers): PRP integrates well. It spreads easily and supports quick downtime.
- Pigment-safe planning: Both can be tailored across skin tones because they use the patient’s own blood, with low risk of pigment change when applied correctly.
- Inflammation and recovery: Both may support reduced inflammation and collagen pacing. Discuss treatment options and intervals to avoid over-treating.
Safety and Chicago-area update (read this)
Patient safety sits first. In April 2024, the CDC reported HIV transmissions linked to “vampire facials” performed at an unlicensed spa—an infection-control failure, not a flaw of PRP/PRF itself. Illinois regulators followed with guidance and reminders for med-spa operations and scope of practice. Choose licensed medical oversight, sterile technique, and FDA-cleared devices.
What to expect in a visit
- Assessment: We review your goals, health history, and any platelet rich plasma therapy you tried.
- Blood draw: A small sample is taken.
- Processing: We prepare platelet concentration appropriate to PRP or PRF.
- Application: We inject or apply with microneedling over the targeted area.
- Recovery: Most clients see mild swelling or redness. Serious PRP treatment for face side effects are rare with proper technique.
- Plan: We schedule sessions and, when helpful, combining PRP or PRF with laser treatments or hyaluronic acid fillers.
PRP vs PRF at a glance
- PRP: Faster prep; fluid; strong track record; ideal with devices or larger coverage; excellent for hair restoration evidence.
- PRF: No anticoagulant; fibrin scaffold; sustained release of growth signals; useful in delicate areas; may need fewer but denser sessions.
Frequently asked questions
Is PRF “better” than PRP?
It depends. For under-eyes and etched fine lines, PRF often performs well due to the fibrin matrix and steady factor release. For broad resurfacing or when pairing with devices, PRP remains a strong choice of effective treatments. Your clinician may recommend both over time, based on response.
Are there side effects?
Expect brief redness, swelling, or tenderness. Bruising can occur with any needle-based care. Infection risk stays very low when teams follow sterile protocol. Always ask about training, sterile processing, and consent.
How many sessions will I need?
Most plans include a series. For texture change, 3 sessions spaced 4–6 weeks apart is common; then maintenance. Your plan adjusts by your benefits of PRP/PRF, age, and baseline condition.
References
- Zwittnig K, et al. Growth Factor Release within Liquid and Solid PRF. Demonstrates prolonged factor release from PRF matrices. PMC
- Diab NAF, et al. Fluid PRF versus PRP for Atrophic Acne Scars. Shows PRF efficacy and safety in facial rejuvenation. PMC
- Davies C, et al. Autologous Platelet Concentrates in Esthetic Medicine. 2024 review on indications and combinations (e.g., lasers, RF). PMC
- Public health & Illinois practice updates: CDC MMWR on unsafe “vampire facial” practices; IDFPR/IDPH med-spa memo and prohibited practices statement. CDCIDFPR+1
