PURE Peptide Programs That Work With Your Biology

Tirzepatide (Zepbound)

Dual GLP-1 / GIP agonist with stronger weight loss outcomes

Tirzepatide is an FDA-approved dual GLP-1 and GIP receptor agonist, marketed as Zepbound for weight management. It represents a meaningful advance over single-agonist medications by targeting two incretin pathways simultaneously, delivering superior weight loss in head-to-head clinical comparisons.

In the SURMOUNT trial program, patients achieved average weight loss of 20 to 25 percent of body weight, with some participants exceeding 25 percent. The dual mechanism provides stronger appetite suppression, improved insulin sensitivity, and metabolic optimization. At PURE, your physician evaluates whether Tirzepatide or Semaglutide is the better fit for your health profile, tolerance history, and goals.

• Administration: Weekly subcutaneous injection with structured dose escalation
• Typical Results: 20 to 25 percent body weight reduction in trials
• Key Advantage: Dual GLP-1/GIP for stronger satiety, better glucose control, greater fat reduction
• Common Effects: Similar GI profile to Semaglutide, typically dose-dependent and transient

AOD-9604

Fat mobilization peptide for GLP-1 plateau support

AOD-9604 is a modified fragment of human growth hormone (the 176 to 191 fragment) designed to retain the fat-mobilizing properties of GH without the systemic effects on blood sugar or cell proliferation. It is frequently layered on top of GLP-1 therapy to support continued fat loss after a plateau.

For patients in our Metabolic Reset Program, AOD-9604 is a go-to tool when the scale stops moving but body composition goals remain. Unlike broad GH therapy, AOD-9604 focuses on adipose tissue, which is especially valuable during the later phases of a medical weight loss program.

• Administration: Daily subcutaneous injection, typically morning
• Common Use: GLP-1 plateau support, body recomposition
• Profile: Generally well-tolerated; minimal systemic GH effects
• Note: Compounded by licensed U.S. pharmacies; prescribed off-label

Selank

Calming, anxiolytic peptide for high-stress patients

Selank is a synthetic analog of the human peptide tuftsin, developed in Russia and used clinically for decades for anxiety and mood support. It modulates GABA and enkephalin pathways, producing a calming effect without sedation and without the dependence profile associated with benzodiazepines.

Selank is a foundation of our Deep Sleep and Brain Reset Program, especially for high-functioning professionals who cannot afford brain fog or sedation. Nasal delivery means no injections, with patients typically noticing subjective calm within the first week.

• Administration: Intranasal spray, 1 to 3 times daily
• Common Benefits: Reduced anxiety, calm focus, improved stress resilience
• Profile: Well-tolerated; non-sedating and non-habit-forming

Semax

Cognitive enhancement and focus peptide

Semax is a synthetic peptide derived from ACTH, developed for neuroprotection and cognitive enhancement. It modulates BDNF (brain-derived neurotrophic factor), dopamine, and serotonin pathways, supporting focus, drive, and mental endurance.

In the Deep Sleep and Brain Reset Program, Semax is often paired with Selank. Patients describe the combination as "calm and clear at the same time." Intranasal administration means rapid onset without the GI effects common to oral nootropics.

• Administration: Intranasal spray, typically morning and early afternoon
• Common Benefits: Improved focus, cognitive stamina, mood support
• Profile: Well-tolerated; avoid late-day dosing to preserve sleep

Sermorelin

Natural growth hormone rhythm, restored

Sermorelin is a growth hormone releasing hormone (GHRH) analog that stimulates your pituitary gland to produce and release its own growth hormone in a natural, pulsatile rhythm. Rather than replacing GH directly (which can suppress endogenous production), Sermorelin takes a gentler, more physiological approach.

In our Longevity and GH Optimization Program, Sermorelin supports declining GH levels that occur with age, promoting sleep quality, lean body composition, skin health, and recovery. It is often paired with Ipamorelin for synergistic effect.

• Administration: 200 to 500 mcg daily via subcutaneous injection at bedtime
• Common Benefits: Deeper sleep, improved recovery, body composition
• Profile: Generally mild; injection site reactions, occasional headache
• Not Appropriate For: Active cancer, untreated hypothyroidism, pregnancy

CJC-1295 + Ipamorelin

The gold-standard GH-release stack for longevity

CJC-1295 and Ipamorelin are growth hormone releasing peptides that stimulate your pituitary to release more of your own GH. CJC-1295 works on the GHRH pathway; Ipamorelin works on the ghrelin receptor. Together, they create a stronger, more natural GH pulse than either alone.

This stack is one of the most popular peptide combinations in Chicago's wellness scene, chosen by patients pursuing recomposition (fat loss with muscle preservation), deeper sleep, and improved recovery. Ipamorelin is notable for its selectivity, meaning it avoids the cortisol and prolactin spikes seen with older GH peptides.

• Administration: Combined evening subcutaneous injection, typically 5 days per week
• Common Benefits: Improved sleep, body composition, skin quality, recovery
• Profile: Well-tolerated; Ipamorelin selectivity avoids cortisol issues

NAD+

The longevity molecule your cells depend on

NAD+ is a coenzyme present in every living cell, essential for converting food into energy, activating sirtuin (longevity) proteins, and supporting DNA repair. Levels decline significantly with age. Supplementing NAD+ may restore critical cellular functions tied to energy, cognition, and healthy aging.

• Administration: IV infusion (250 to 500 mg), subcutaneous injection, or oral precursor
• Common Benefits: Improved energy, mental clarity, cellular resilience
• Profile: Mild flushing with IV; slow drip minimizes

GHK-Cu (Copper Peptide)

Regenerative skin and hair signaling, restored

GHK-Cu is a naturally occurring copper peptide that signals cells to produce collagen, elastin, and glycosaminoglycans while exerting anti-inflammatory and antioxidant effects. Endogenous levels decline from 200 ng/mL at age 20 to roughly 80 ng/mL by age 60, which partially explains the visible changes in skin and hair in mid-life.

At PURE, GHK-Cu is a centerpiece of the Regenerative Beauty and Hair Revival Program. It pairs beautifully with our in-clinic Microneedling, Morpheus8, and laser resurfacing services, amplifying the regenerative response of those treatments.

• Administration: Topical (1 to 3 percent), subcutaneous injection (1 to 5 mg/day), or microneedling infusion
• Common Benefits: Improved skin texture, firmness, hair density
• Profile: Mild irritation possible; rare temporary purging
• Not Appropriate For: Wilson's disease, concurrent high-dose vitamin C

BPC-157

Tissue repair and angiogenesis peptide

BPC-157 (Body Protection Compound 157) is a synthetic peptide derived from a protein found in gastric juice. In preclinical research, it demonstrates broad tissue-repair effects, promoting angiogenesis (new blood vessel formation), collagen synthesis, and inflammation modulation, particularly in tissues with poor blood supply like tendons and ligaments.

At PURE, BPC-157 is a centerpiece of the Total Recovery Protocol, used for tendon and ligament concerns, joint support, and post-surgical recovery. Patients frequently pair it with TB-500 for systemic healing support.

• Administration: Subcutaneous injection, 250 to 500 mcg daily during loading phase
• Common Use: Tendinopathy, joint concerns, post-surgical recovery support
• Profile: Generally well-tolerated; mild injection site reactions
• Regulatory Note: Compounded by U.S. pharmacies; not FDA-approved for these uses

TB-500 / Thymosin Beta-4

Systemic tissue repair and cell migration support

TB-500 is a synthetic form of Thymosin Beta-4, a peptide naturally present in almost all human and animal cells. It plays a central role in tissue repair by regulating actin, a protein essential for cell migration, new blood vessel formation, and muscle repair. Its systemic action circulates throughout the body, making it effective for muscle strains, joint discomfort, connective tissue injuries, and post-surgical healing.

• Administration: Subcutaneous injection, 2 to 3 times per week during loading phase
• Common Use: Systemic healing, muscle strain, joint support
• Profile: Mild fatigue, headache, injection site reactions possible

MOTS-c

Mitochondrial-derived peptide for cellular energy

MOTS-c is a mitochondrial-derived peptide that activates AMPK, the master metabolic energy sensor (the same pathway triggered by exercise). It supports mitochondrial biogenesis, insulin sensitivity, and cellular vitality. Think of it as a bridge between exercise science and longevity medicine.

• Administration: 5 to 10 mg per week via subcutaneous injection, typically cycled 4 to 8 weeks
• Common Benefits: Improved metabolic flexibility, cellular energy, endurance
• Profile: Generally mild; injection site irritation possible